The way it is taught on the DVD, it doesn't matter if
you hold the deck in your right
or left hand. Most of us hold the deck in our left hands, opposite way that Andrei & JB do it.
Typically,
most left handed people (those who
write with their
left hand) hold the deck in their right hand.
Typically,
most right handed people (those who
write with their
right hand) hold the deck in their left hand.
I am personally left handed, but I also hold the deck in my left hand. I am the exception to the statistics.
No matter how you hold the deck (unless you hold it with your feet, your elbows or your nunchucks), you should be able to learn all of the material on Genesis just as well as someone who holds the deck in the hand opposite as you do. It's really not that complicated - go ahead and buy it.
On a side note, according to cognitive psychology, females will have a harder time processing 3D concepts than men, so they are at a slight biological disadvantage when learning cardistry. Especially if they have to switch between left and right handed ideas when learning.
I hope that helps.
Peace,
-Tim